Eman H Abdel-Rahman
National Research Center, Egypt
Title: Insight into development of fasciola vaccines
Biography
Biography: Eman H Abdel-Rahman
Abstract
Despite progress in technologies of vaccine development and multiple developed vaccine candidates against fasciolosis, there are no commercial vaccines of fasciola infections yet. This failure probably attributed to choice of antigen, choice of adjuvant, route of delivery, dose and production costs. Among the major potential vaccine candidates are fatty acid binding proteins, cathepsin proteases, glutathione S-transferases, haemoglobulin, thioredoxin peroxidase, leucine aminopeptidase and a saposin-like proteins. Fasciola parasite can potentially evade host immune responses. This immune modulation explains the slow host response and some times poor protection. Function neutralization of Fasciola immunomodulatory molecules is essential for development of anti- Fasciola protective immunity. Updated knowledge of immune modulation by Fasciola parasite of different hosts, defining what progress is being made on the use of helminth immunomodulators in vaccination and what effect this helminth infections has on host immune competence will be presented.